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Allosteric tertiary interactions pre-organize the c-di-GMP riboswitch and accelerate ligand binding
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger important for physiologic adaptation and virulence. Class-I c-di-GMP riboswitches are phylogenetically widespread and thought to mediate pleiotropic genetic responses to the second messenger. Previous studies suggest that the RNA aptamer...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3356476/ https://ncbi.nlm.nih.gov/pubmed/22380737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300014u |
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