A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1

Brain angiogenesis inhibitor 1 (BAI1), an orphan GPCR-type seven transmembrane receptor, was recently found mutated or silenced in multiple human cancers and can interfere with tumor growth when overexpressed. Yet, little is known about the molecular mechanisms through which this novel tumor suppres...

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Autors principals: Cork, Sarah M., Kaur, Balveen, Devi, Narra S., Cooper, Lee, Saltz, Joel H., Sandberg, Eric M., Kaluz, Stefan, Van Meir, Erwin G.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355202/
https://ncbi.nlm.nih.gov/pubmed/22330140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.1
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