A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1

Brain angiogenesis inhibitor 1 (BAI1), an orphan GPCR-type seven transmembrane receptor, was recently found mutated or silenced in multiple human cancers and can interfere with tumor growth when overexpressed. Yet, little is known about the molecular mechanisms through which this novel tumor suppres...

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Hauptverfasser: Cork, Sarah M., Kaur, Balveen, Devi, Narra S., Cooper, Lee, Saltz, Joel H., Sandberg, Eric M., Kaluz, Stefan, Van Meir, Erwin G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355202/
https://ncbi.nlm.nih.gov/pubmed/22330140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.1
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