Differential Sensitivity of Glioma- versus Lung Cancer-specific EGFR mutations to EGFR Kinase Inhibitors

Activation of the epidermal growth factor receptor (EGFR) in glioblastoma (GBM) occurs through mutations or deletions in the extracellular (EC) domain. Unlike lung cancers with EGFR kinase domain (KD) mutations, GBMs respond poorly to the EGFR inhibitor erlotinib. Using RNAi, we show that GBM cells...

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Autors principals: Vivanco, Igor, Robins, H. Ian, Rohle, Daniel, Campos, Carl, Grommes, Christian, Nghiemphu, Phioanh Leia, Kubek, Sara, Oldrini, Barbara, Chheda, Milan G., Yannuzzi, Nicolas, Tao, Hui, Zhu, Shaojun, Iwanami, Akio, Kuga, Daisuke, Dang, Julie, Pedraza, Alicia, Brennan, Cameron W., Heguy, Adriana, Liau, Linda M., Lieberman, Frank, Yung, W.K. Alfred, Gilbert, Mark R., Reardon, David A., Drappatz, Jan, Wen, Patrick Y., Lamborn, Kathleen R., Chang, Susan M., Prados, Michael D., Fine, Howard A., Horvath, Steve, Wu, Nian, Lassman, Andrew B., DeAngelis, Lisa M., Yong, William H., Kuhn, John G., Mischel, Paul S., Mehta, Minesh P., Cloughesy, Timothy F., Mellinghoff, Ingo K.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354723/
https://ncbi.nlm.nih.gov/pubmed/22588883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0284
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