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Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)

Specific inhibitors of the production of reactive oxygen species (ROS) by the NADPH oxidases (Nox’s) are potentially important therapeutic agents in the wide range of human diseases that are characterized by excessive ROS production. It has been proposed that VAS2870 (3-benzyl-7-(2-benzoxazolyl)thio...

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Dettagli Bibliografici
Autori principali: Sun, Qi-An, Hess, Douglas T., Wang, Benlian, Miyagi, Masaru, Stamler, Jonathan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354571/
https://ncbi.nlm.nih.gov/pubmed/22406319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.02.046
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