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MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function
p53 mutations have profound effects on non-small-cell lung cancer (NSCLC) resistance to chemotherapeutic treatments. Mutant p53 proteins are usually expressed at high levels in tumors, where they exert oncogenic functions. Here we show that p53R175H, a hotspot p53 mutant, induces microRNA (miRNA)-12...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3354056/ https://ncbi.nlm.nih.gov/pubmed/22193543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.190 |
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