Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity

Interferon (IFN)-β inhibits cell proliferation and affects cell cycle in keratinocytes transformed by both mucosal high risk Human Papilloma Virus (HPV) and cutaneous HPV E6 and E7 proteins. In particular, upon longer IFN-β treatments, cutaneous HPV38 expressing cells undergo senescence. IFN-β appea...

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Detalhes bibliográficos
Main Authors: Chiantore, Maria V., Vannucchi, Serena, Accardi, Rosita, Tommasino, Massimo, Percario, Zulema A., Vaccari, Gabriele, Affabris, Elisabetta, Fiorucci, Gianna, Romeo, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353995/
https://ncbi.nlm.nih.gov/pubmed/22615843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036909
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