HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO(2) Production and Neurotoxic Activity

BACKGROUND: The potential role of the human immunodeficiency virus-1 (HIV-1) accessory protein Nef in the pathogenesis of neuroAIDS is still poorly understood. Nef is a molecular adapter that influences several cellular signal transduction events and membrane trafficking. In human macrophages, Nef e...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mangino, Giorgio, Famiglietti, Marylinda, Capone, Caterina, Veroni, Caterina, Percario, Zulema Antonia, Leone, Stefano, Fiorucci, Gianna, Lülf, Sebastian, Romeo, Giovanna, Agresti, Cristina, Persichini, Tiziana, Geyer, Matthias, Affabris, Elisabetta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465743/
https://ncbi.nlm.nih.gov/pubmed/26066624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130189
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