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Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation

AIMS: Binge drinking often triggers compromised myocardial contractile function while activating AMP-activated protein kinase (AMPK). Given the role of AMPK in the initiation of autophagy through the mammalian target of rapamycin complex 1 (mTORC1) and Unc51-like kinase (ULK1), this study was design...

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Detalhes bibliográficos
Main Authors: Guo, Rui, Ren, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353804/
https://ncbi.nlm.nih.gov/pubmed/22451512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs127
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