Amplification of CRKL induces transformation and EGFR inhibitor resistance in human non small cell lung cancers

We previously identified a region of recurrent amplification on chromosome 22q11.21 in a subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed in non-small cell lung cancer (NSCLC) cells that harbor 22q11.21 amplifications. Ov...

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Detalhes bibliográficos
Main Authors: Cheung, Hiu Wing, Du, Jinyan, Boehm, Jesse S., He, Frank, Weir, Barbara A., Wang, Xiaoxing, Butaney, Mohit, Sequist, Lecia V., Luo, Biao, Engelman, Jeffrey A., Root, David E., Meyerson, Matthew, Golub, Todd R., Jänne, Pasi A., Hahn, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353720/
https://ncbi.nlm.nih.gov/pubmed/22586683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0046
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