Amplification of CRKL induces transformation and EGFR inhibitor resistance in human non small cell lung cancers

We previously identified a region of recurrent amplification on chromosome 22q11.21 in a subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed in non-small cell lung cancer (NSCLC) cells that harbor 22q11.21 amplifications. Ov...

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Détails bibliographiques
Auteurs principaux: Cheung, Hiu Wing, Du, Jinyan, Boehm, Jesse S., He, Frank, Weir, Barbara A., Wang, Xiaoxing, Butaney, Mohit, Sequist, Lecia V., Luo, Biao, Engelman, Jeffrey A., Root, David E., Meyerson, Matthew, Golub, Todd R., Jänne, Pasi A., Hahn, William C.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353720/
https://ncbi.nlm.nih.gov/pubmed/22586683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0046
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