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Amplification of CRKL induces transformation and EGFR inhibitor resistance in human non small cell lung cancers
We previously identified a region of recurrent amplification on chromosome 22q11.21 in a subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed in non-small cell lung cancer (NSCLC) cells that harbor 22q11.21 amplifications. Ov...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3353720/ https://ncbi.nlm.nih.gov/pubmed/22586683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0046 |
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