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Site-Selective Glycosylation of Hemoglobin with Variable Molecular Weight Oligosaccharides: A Potential Alternative to PEGylation
Poly(ethylene glycol) (PEG) conjugation (i.e. PEGylation) is a commonly used strategy to increase the circulatory half-life of therapeutic proteins and colloids, however, few viable alternatives exist to replicate its functions. Herein, we report a method for the rapid site-selective glycosylation o...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3353419/ https://ncbi.nlm.nih.gov/pubmed/22489605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja300893t |
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