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Bio-inspired synthesis and biological evaluation of a colchicine-related compound library

A bio-inspired investigation of the reactions of substrates of type 1 with VOF(3) and PIFA [phenyliodine(III) bis(trifluoroacetate)] led to a collection of colchicine-like compounds 2–5 and related systems. Biological evaluation revealed that some of the synthesized products had significant cytotoxi...

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Autors principals: Nicolaou, K. C., Valiulin, Roman A., Pokorski, Jonathan K., Chang, Vicki, Chen, Jason S.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353021/
https://ncbi.nlm.nih.gov/pubmed/22542017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.007
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