Enzymatic Analysis of Recombinant Japanese Encephalitis Virus NS2B(H)-NS3pro Protease with Fluorogenic Model Peptide Substrates

BACKGROUND: Japanese encephalitis virus (JEV), a member of the Flaviviridae family, causes around 68,000 encephalitis cases annually, of which 20–30% are fatal, while 30–50% of the recovered cases develop severe neurological sequelae. Specific antivirals for JEV would be of great importance, particu...

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Autors principals: Junaid, Muhammad, Chalayut, Chakard, Sehgelmeble Torrejon, Anna, Angsuthanasombat, Chanan, Shutava, Iryna, Lapins, Maris, Wikberg, Jarl E. S., Katzenmeier, Gerd
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352935/
https://ncbi.nlm.nih.gov/pubmed/22615830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036872
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