Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells

Multi-drug resistance (MDR), an unfavorable factor compromising treatment efficacy of anticancer drugs, involves upregulated ATP binding cassette (ABC) transporters and activated Sonic hedgehog (Shh) signaling. By preparing human breast cancer MCF-7 cells resistant to doxorubicin (DOX), we examined...

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Bibliografiske detaljer
Main Authors: Chen, Yu-Jen, Kuo, Cheng-Deng, Chen, Szu-Han, Chen, Wei-Jen, Huang, Wen-Chien, Chao, K. S. Clifford, Liao, Hui-Fen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352857/
https://ncbi.nlm.nih.gov/pubmed/22615870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037006
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