Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells

Multi-drug resistance (MDR), an unfavorable factor compromising treatment efficacy of anticancer drugs, involves upregulated ATP binding cassette (ABC) transporters and activated Sonic hedgehog (Shh) signaling. By preparing human breast cancer MCF-7 cells resistant to doxorubicin (DOX), we examined...

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Detalhes bibliográficos
Main Authors: Chen, Yu-Jen, Kuo, Cheng-Deng, Chen, Szu-Han, Chen, Wei-Jen, Huang, Wen-Chien, Chao, K. S. Clifford, Liao, Hui-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352857/
https://ncbi.nlm.nih.gov/pubmed/22615870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037006
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