Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells

Multi-drug resistance (MDR), an unfavorable factor compromising treatment efficacy of anticancer drugs, involves upregulated ATP binding cassette (ABC) transporters and activated Sonic hedgehog (Shh) signaling. By preparing human breast cancer MCF-7 cells resistant to doxorubicin (DOX), we examined...

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Hlavní autoři: Chen, Yu-Jen, Kuo, Cheng-Deng, Chen, Szu-Han, Chen, Wei-Jen, Huang, Wen-Chien, Chao, K. S. Clifford, Liao, Hui-Fen
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352857/
https://ncbi.nlm.nih.gov/pubmed/22615870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037006
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