Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells

Multi-drug resistance (MDR), an unfavorable factor compromising treatment efficacy of anticancer drugs, involves upregulated ATP binding cassette (ABC) transporters and activated Sonic hedgehog (Shh) signaling. By preparing human breast cancer MCF-7 cells resistant to doxorubicin (DOX), we examined...

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Autores principales: Chen, Yu-Jen, Kuo, Cheng-Deng, Chen, Szu-Han, Chen, Wei-Jen, Huang, Wen-Chien, Chao, K. S. Clifford, Liao, Hui-Fen
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352857/
https://ncbi.nlm.nih.gov/pubmed/22615870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037006
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