Sensitive and specific detection of sporadic Creutzfeldt–Jakob disease brain prion protein using real-time quaking-induced conversion

Real-time quaking-induced conversion (RT-QuIC) is an assay in which disease-associated prion protein (PrP) initiates a rapid conformational transition in recombinant PrP (recPrP), resulting in the formation of amyloid that can be monitored in real time using the dye thioflavin T. It therefore has po...

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Hauptverfasser: Peden, Alexander H., McGuire, Lynne I., Appleford, Nigel E. J., Mallinson, Gary, Wilham, Jason M., Orrú, Christina D., Caughey, Byron, Ironside, James W., Knight, Richard S., Will, Robert G., Green, Alison J. E., Head, Mark W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for General Microbiology 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352348/
https://ncbi.nlm.nih.gov/pubmed/22031526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.033365-0
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