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Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

BACKGROUND: Type 2 diabetes is a risk factor for Alzheimer's disease (AD), most likely linked to an impairment of insulin signalling in the brain. Therefore, drugs that enhance insulin signalling may have therapeutic potential for AD. Liraglutide (Victoza) and exenatide (Byetta) are novel long-...

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Bibliographic Details
Main Authors: Hunter, Kerry, Hölscher, Christian
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352246/
https://ncbi.nlm.nih.gov/pubmed/22443187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-13-33
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