Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9

BACKGROUND: Activation of spinal cord glial cells such as microglia and astrocytes has been shown to regulate chronic opioid-induced antinociceptive tolerance and hyperalgesia, due to spinal up-regulation of the proinflammatory cytokines such as interleukin-1 beta (IL-1β). Matrix metalloprotease-9 (...

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Main Authors: Berta, Temugin, Liu, Tong, Liu, Yen-Chin, Xu, Zhen-Zhong, Ji, Ru-Rong
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352126/
https://ncbi.nlm.nih.gov/pubmed/22439811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-18
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