Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling

Fusidic acid (FA) is a bacteriostatic antibiotic that locks elongation factor G (EF-G) to the ribosome after GTP hydrolysis during elongation and ribosome recycling. The plasmid pUB101-encoded protein FusB causes FA resistance in clinical isolates of Staphylococcus aureus through an interaction with...

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Bibliographische Detailangaben
Hauptverfasser: Guo, Xiaohu, Peisker, Kristin, Bäckbro, Kristina, Chen, Yang, Koripella, Ravi Kiran, Mandava, Chandra Sekhar, Sanyal, Suparna, Selmer, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352095/
https://ncbi.nlm.nih.gov/pubmed/22645663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.120016
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