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Fusidic Acid Targets Elongation Factor G in Several Stages of Translocation on the Bacterial Ribosome
The antibiotic fusidic acid (FA) targets elongation factor G (EF-G) and inhibits ribosomal peptide elongation and ribosome recycling, but deeper mechanistic aspects of FA action have remained unknown. Using quench flow and stopped flow experiments in a biochemical system for protein synthesis and ta...
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| Publicado en: | J Biol Chem |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4319013/ https://ncbi.nlm.nih.gov/pubmed/25451927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611608 |
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