Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells

Normally, cell proliferation and death are carefully balanced in higher eukaryotes, but one of the most important regulatory mechanisms, apoptosis, is upset in many malignancies, including hepatocellular-derived ones. Therefore, reinforcing cell death often is mandatory in anticancer therapy. We pre...

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Detalhes bibliográficos
Main Authors: Ullio, Chiara, Casas, Josefina, Brunk, Ulf T., Sala, Giuseppina, Fabriàs, Gemma, Ghidoni, Riccardo, Bonelli, Gabriella, Baccino, Francesco M., Autelli, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351820/
https://ncbi.nlm.nih.gov/pubmed/22454477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M022384
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