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Rapid Transcriptional Pulsing Dynamics of High Expressing Retroviral Transgenes in Embryonic Stem Cells

Single cell imaging studies suggest that transcription is not continuous and occurs as discrete pulses of gene activity. To study mechanisms by which retroviral transgenes can transcribe to high levels, we used the MS2 system to visualize transcriptional dynamics of high expressing proviral integrat...

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Detalhes bibliográficos
Main Authors: Lo, Mandy Y. M., Rival-Gervier, Sylvie, Pasceri, Peter, Ellis, James
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351450/
https://ncbi.nlm.nih.gov/pubmed/22606340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037130
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