Kinetics and Epigenetics of Retroviral Silencing in Mouse Embryonic Stem Cells Defined by Deletion of the D4Z4 Element

Retroviral vectors are silenced in embryonic stem (ES) cells by epigenetic mechanisms whose kinetics are poorly understood. We show here that a 3′D4Z4 insulator directs retroviral expression with persistent but variable expression for up to 5 months. Combining an internal 3′D4Z4 with HS4 insulators...

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Hlavní autoři: Rival-Gervier, Sylvie, Lo, Mandy YM, Khattak, Shahryar, Pasceri, Peter, Lorincz, Matthew C, Ellis, James
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734652/
https://ncbi.nlm.nih.gov/pubmed/23752310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.131
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