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Transgenic Expression of Nonclassically Secreted FGF Suppresses Kidney Repair

FGF1 is a signal peptide-less nonclassically released growth factor that is involved in angiogenesis, tissue repair, inflammation, and carcinogenesis. The effects of nonclassical FGF export in vivo are not sufficiently studied. We produced transgenic mice expressing FGF1 in endothelial cells (EC), w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kirov, Aleksandr, Duarte, Maria, Guay, Justin, Karolak, Michele, Yan, Cong, Oxburgh, Leif, Prudovsky, Igor
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351418/
https://ncbi.nlm.nih.gov/pubmed/22606265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036485
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