CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant

Regardless of the route of transmission, R5-tropic HIV-1 predominates early in infection, rendering C-C chemokine receptor type 5 (CCR5) antagonists as attractive agents not only for antiretroviral therapy but also for prevention. Here, we report the specificity, potency, and underlying mechanism of...

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Detalhes bibliográficos
Main Authors: Kang, Yuanxi, Wu, Zhiwei, Lau, Terrence C. K., Lu, Xiaofan, Liu, Li, Cheung, Allen K. L., Tan, Zhiwu, Ng, Jenny, Liang, Jianguo, Wang, Haibo, Li, Saikam, Zheng, Bojian, Li, Ben, Chen, Li, Chen, Zhiwei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351311/
https://ncbi.nlm.nih.gov/pubmed/22447925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.354084
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