TRAF6 Protein Couples Toll-like Receptor 4 Signaling to Src Family Kinase Activation and Opening of Paracellular Pathway in Human Lung Microvascular Endothelia

Gram-negative bacteria release lipopolysaccharide (LPS) into the bloodstream. Here, it engages Toll-like receptor (TLR) 4 expressed in human lung microvascular endothelia (HMVEC-Ls) to open the paracellular pathway through Src family kinase (SFK) activation. The signaling molecules that couple TLR4...

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Detalhes bibliográficos
Main Authors: Liu, Anguo, Gong, Ping, Hyun, Sang W., Wang, Kent Z. Q., Cates, Elizabeth A., Perkins, Darren, Bannerman, Douglas D., Puché, Adam C., Toshchakov, Vladimir Y., Fang, Shengyun, Auron, Philip E., Vogel, Stefanie N., Goldblum, Simeon E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351307/
https://ncbi.nlm.nih.gov/pubmed/22447928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310102
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