TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia

Bacterial lipopolysaccharide (LPS) is a key mediator in the vascular leak syndromes associated with Gram-negative bacterial infections. LPS opens the paracellular pathway in pulmonary vascular endothelia through protein tyrosine phosphorylation. We now have identified the protein-tyrosine kinases (P...

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Détails bibliographiques
Auteurs principaux: Gong, Ping, Angelini, Daniel J., Yang, Shiqi, Xia, Guanjun, Cross, Alan S., Mann, Dean, Bannerman, Douglas D., Vogel, Stefanie N., Goldblum, Simeon E.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Mechanisms of Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442341/
https://ncbi.nlm.nih.gov/pubmed/18326860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707986200
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