Sulforaphane Induction of p21(Cip1) Cyclin-dependent Kinase Inhibitor Expression Requires p53 and Sp1 Transcription Factors and Is p53-dependent

Sulforaphane (SFN) is an important cancer preventive agent derived from cruciferous vegetables. We show that SFN treatment suppresses normal human keratinocyte proliferation via a mechanism that involves increased expression of p21(Cip1). SFN treatment produces a concentration-dependent increase in...

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Detalhes bibliográficos
Main Authors: Chew, Yap Ching, Adhikary, Gautam, Wilson, Gerald M., Xu, Wen, Eckert, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351300/
https://ncbi.nlm.nih.gov/pubmed/22427654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.305292
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