Protein Kinase C (PKC) δ Suppresses Keratinocyte Proliferation by Increasing p21(Cip1) Level by a KLF4 Transcription Factor-dependent Mechanism

PKCδ increases keratinocyte differentiation and suppresses keratinocyte proliferation and survival. However, the mechanism of proliferation suppression is not well understood. The present studies show that PKCδ overexpression increases p21(Cip1) mRNA and protein level and promoter activity and that...

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Detalhes bibliográficos
Main Authors: Chew, Yap Ching, Adhikary, Gautam, Wilson, Gerald M., Reece, E. Albert, Eckert, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190685/
https://ncbi.nlm.nih.gov/pubmed/21652709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205245
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