Protein Kinase C (PKC) δ Suppresses Keratinocyte Proliferation by Increasing p21(Cip1) Level by a KLF4 Transcription Factor-dependent Mechanism

PKCδ increases keratinocyte differentiation and suppresses keratinocyte proliferation and survival. However, the mechanism of proliferation suppression is not well understood. The present studies show that PKCδ overexpression increases p21(Cip1) mRNA and protein level and promoter activity and that...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Chew, Yap Ching, Adhikary, Gautam, Wilson, Gerald M., Reece, E. Albert, Eckert, Richard L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190685/
https://ncbi.nlm.nih.gov/pubmed/21652709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205245
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky