The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary

Human telomerase RNA (hTR) contains several guanine tracts at its 5′-end that can form a G4-quadruplex structure. Previous evidence suggests that a G4-quadruplex within this region disrupts the formation of an important structure within hTR known as the P1 helix, a critical element in defining the t...

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Bibliographic Details
Main Authors: Booy, E. P., Meier, M., Okun, N., Novakowski, S. K., Xiong, S., Stetefeld, J., McKenna, S. A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351167/
https://ncbi.nlm.nih.gov/pubmed/22238380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1306
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