A Long ncRNA Links Copy Number Variation to a Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy

Repetitive sequences account for more than 50% of the human genome. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease associated with reduction in the copy number of the D4Z4 repeat mapping to 4q35. By an unknown mechanism, D4Z4 deletion causes an epigenetic switch leadi...

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Hlavní autoři: Cabianca, Daphne S., Casa, Valentina, Bodega, Beatrice, Xynos, Alexandros, Ginelli, Enrico, Tanaka, Yujiro, Gabellini, Davide
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350859/
https://ncbi.nlm.nih.gov/pubmed/22541069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.035
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