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Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans to create Lipoxygenase Inhibitors
[Image: see text] Sclerotiorin, an azaphilone polyketide, is a bioactive natural product known to inhibit 15-lipoxygenase and many other biological targets. To readily access sclerotiorin and analogs, we developed a 2–3 step semisynthetic route to produce a variety of azaphilones starting from an ad...
Bewaard in:
| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3350772/ https://ncbi.nlm.nih.gov/pubmed/22296232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol203094k |
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