Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging

We have previously used cryo-electron tomography combined with sub-volume averaging and classification to obtain 3D structures of macromolecular assemblies in cases where a single dominant species was present, and applied these methods to the analysis of a variety of trimeric HIV-1 and SIV envelope...

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Hauptverfasser: Frank, Gabriel A., Bartesaghi, Alberto, Kuybeda, Oleg, Borgnia, Mario J., White, Tommi A., Sapiro, Guillermo, Subramaniam, Sriram
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350607/
https://ncbi.nlm.nih.gov/pubmed/22248450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2012.01.004
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