Depletion of Cytotoxic T-Cells Does Not Protect NUP98-HOXD13 Mice from Myelodysplastic Syndrome but Reveals a Modest Tumor Immunosurveillance Effect

Myelodysplastic syndrome (MDS) and aplastic anemia (AA) patients both present with symptoms of bone marrow failure. In many AA patients, these features are thought to result from an oligoclonal expansion of cytotoxic T-cells that destroy haematopoietic stem or progenitor cells. This notion is suppor...

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Bibliographic Details
Main Authors: Gough, Sheryl M., Chung, Yang Jo, Aplan, Peter D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350481/
https://ncbi.nlm.nih.gov/pubmed/22606303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036876
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