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Interaction of topoisomerase 1 with the transcribed region of the Drosophila HSP 70 heat shock gene.

Topoisomerase I cleavage sites have been mapped in vivo on the Hsp70 heat shock gene of Drosophila melanogaster cells using the drug camptothecin. Topoisomerase I cleavage was only observed when the Hsp70 gene was transcriptionally active. Site-specific single-strand DNA cleavage by topoisomerase I...

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Autors principals: Kroeger, P E, Rowe, T C
Format: Artigo
Idioma:Inglês
Publicat: 1989
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC335022/
https://ncbi.nlm.nih.gov/pubmed/2555773
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