D469del-COMP Retention in Chondrocytes Stimulates Caspase-Independent Necroptosis

Mutations in the cartilage oligomeric matrix protein gene (COMP) cause pseudoachondroplasia (PSACH). This dysplasia results from the intracellular retention of mutant COMP protein and premature death of growth-plate chondrocytes. Toward better understanding of these underlying mechanisms, we examine...

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Main Authors: Coustry, Françoise, Posey, Karen L., Liu, Peiman, Alcorn, Joseph L., Hecht, Jacqueline T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349870/
https://ncbi.nlm.nih.gov/pubmed/22154936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.10.033
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