De Novo Peptide Design with C3a Receptor Agonist and Antagonist Activities: Theoretical Predictions and Experimental Validation()

Targeting the complement component 3a receptor (C3aR) with selective agonists or antagonists is believed to be a viable therapeutic option for several diseases such as stroke, heart attack, reper-fusion injuries, and rheumatoid arthritis. We designed a number of agonists, partial agonists, and antag...

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Main Authors: Bellows-Peterson, Meghan L., Fung, Ho Ki, Floudas, Christodoulos A., Kieslich, Chris A., Zhang, Li, Morikis, Dimitrios, Wareham, Kathryn J., Monk, Peter N., Hawksworth, Owen A., Woodruff, Trent
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349770/
https://ncbi.nlm.nih.gov/pubmed/22500977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201609k
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