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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

The aim of de novo protein design is to find the amino acid sequences that will fold into a desired 3-dimensional structure with improvements in specific properties, such as binding affinity, agonist or antagonist behavior, or stability, relative to the native sequence. Protein design lies at the ce...

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Detalhes bibliográficos
Main Authors: Smadbeck, James, Peterson, Meghan B., Khoury, George A., Taylor, Martin S., Floudas, Christodoulos A.
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846368/
https://ncbi.nlm.nih.gov/pubmed/23912941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/50476
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