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Modeling HIV-1 Drug Resistance as Episodic Directional Selection
The evolution of substitutions conferring drug resistance to HIV-1 is both episodic, occurring when patients are on antiretroviral therapy, and strongly directional, with site-specific resistant residues increasing in frequency over time. While methods exist to detect episodic diversifying selection...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3349733/ https://ncbi.nlm.nih.gov/pubmed/22589711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002507 |
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