Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity

BACKGROUND: Mutations in the substrate of HIV-1 protease, especially changes in the NC/p1 cleavage site, can directly contribute to protease inhibitor (PI) resistance and also compensate for defects in viral replicative capacity (RC) due to a drug resistant protease. These NC/p1 changes are known to...

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Autori principali: van Maarseveen, Noortje M, Andersson, Dan, Lepšík, Martin, Fun, Axel, Schipper, Pauline J, de Jong, Dorien, Boucher, Charles AB, Nijhuis, Monique
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349524/
https://ncbi.nlm.nih.gov/pubmed/22462820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-29
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