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Stochastic processes strongly influence HIV-1 evolution during suboptimal protease-inhibitor therapy

It has long been assumed that HIV-1 evolution is best described by deterministic evolutionary models because of the large population size. Recently, however, it was suggested that the effective population size (N(e)) may be rather small, thereby allowing chance to influence evolution, a situation be...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Nijhuis, Monique, Boucher, Charles A. B., Schipper, Pauline, Leitner, Thomas, Schuurman, Rob, Albert, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24392/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826719/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.24.14441
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