Stochastic processes strongly influence HIV-1 evolution during suboptimal protease-inhibitor therapy

It has long been assumed that HIV-1 evolution is best described by deterministic evolutionary models because of the large population size. Recently, however, it was suggested that the effective population size (N(e)) may be rather small, thereby allowing chance to influence evolution, a situation be...

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Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Nijhuis, Monique, Boucher, Charles A. B., Schipper, Pauline, Leitner, Thomas, Schuurman, Rob, Albert, Jan
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 1998
Θέματα:	Biological Sciences
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24392/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.24.14441
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