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DNA Immunization Against Amyloid beta 42 has High Potential as Safe Therapy for Alzheimer’s Disease as it Diminishes Antigen-Specific Th1 and Th17 Cell Proliferation

The pathogenesis of Alzheimer’s disease (AD) has been strongly associated with the accumulation of amyloid beta (Aβ) peptides in brain, and immunotherapy targeting Aβ provides potential for AD prevention. A clinical trial in which AD patients were immunized with Aβ42 peptide was stopped when 6% of p...

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Bibliographic Details
Main Authors: Lambracht-Washington, Doris, Qu, Bao-Xi, Fu, Min, Anderson, Larry D., Stüve, Olaf, Eagar, Todd N., Rosenberg, Roger N.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349443/
https://ncbi.nlm.nih.gov/pubmed/21625960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10571-011-9680-7
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