Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2

Mutations in the genes encoding LRRK2 and α-synuclein cause autosomal dominant forms of familial Parkinson's disease (PD). Fibrillar forms of α-synuclein are a major component of Lewy bodies, the intracytoplasmic proteinaceous inclusions that are a pathological hallmark of idiopathic and certai...

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Main Authors: Daher, João Paulo L., Pletnikova, Olga, Biskup, Saskia, Musso, Alessandra, Gellhaar, Sandra, Galter, Dagmar, Troncoso, Juan C., Lee, Michael K., Dawson, Ted M., Dawson, Valina L., Moore, Darren J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349422/
https://ncbi.nlm.nih.gov/pubmed/22357653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds057
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