Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

Tubuloglomerular feedback (TGF) stabilizes nephron function from minute to minute and adapts to different steady-state inputs to maintain this capability. Such adaptation inherently renders TGF less efficient at buffering long-term disturbances, but the magnitude of loss is unknown. We undertook the...

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Главные авторы: Thomson, Scott C., Rieg, Timo, Miracle, Cynthia, Mansoury, Hadi, Whaley, Jean, Vallon, Volker, Singh, Prabhleen
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2012
Предметы:
Fluid and Electrolyte Homeostasis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349378/
https://ncbi.nlm.nih.gov/pubmed/21940401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00357.2011
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