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Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt

Heightened sensitivity of the diabetic proximal tubule to dietary salt leads to a paradoxical effect of salt on glomerular filtration rate (GFR) via tubuloglomerular feedback. Diabetic hyperfiltration is a feedback response to growth and hyperreabsorption by the proximal tubule. The present studies...

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Detalhes bibliográficos
Main Authors: Miracle, Cynthia M., Rieg, Timo, Mansoury, Hadi, Vallon, Volker, Thomson, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576161/
https://ncbi.nlm.nih.gov/pubmed/18562630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00491.2007
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