A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours

BACKGROUND: The objectives of this phase I study were to assess the safety and tolerability of E7080 in patients with advanced, refractory solid tumours; to determine the maximum tolerated dose (MTD) and pharmacokinetics profile of E7080; and to explore preliminary evidence of its anti-tumour effica...

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Detalhes bibliográficos
Main Authors: Boss, D S, Glen, H, Beijnen, J H, Keesen, M, Morrison, R, Tait, B, Copalu, W, Mazur, A, Wanders, J, O'Brien, J P, Schellens, J H M, Evans, T R J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349182/
https://ncbi.nlm.nih.gov/pubmed/22516948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.154
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