Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra®, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours

This phase I trial was designed to determine the safety and maximum tolerated dose (MTD) of tipifarnib in combination with gemcitabine and cisplatin in patients with advanced solid tumours. Furthermore, the pharmacokinetics of each of these agents was evaluated. Patients were treated with tipifarnib...

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Detalhes bibliográficos
Main Authors: Siegel-Lakhai, W S, Crul, M, Zhang, S, Sparidans, R W, Pluim, D, Howes, A, Solanki, B, Beijnen, J H, Schellens, J H M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361514/
https://ncbi.nlm.nih.gov/pubmed/16251868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602850
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