Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells

Despite major advances, multiple myeloma (MM) remains an incurable malignancy. Recently we have found that disease stabilization was achieved in 64% of patients with advanced MM treated with the farnesyltransferase inhibitor R115777 (Zarnestra) in a phase 2 clinical trial. In order to enhance R11577...

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Detalhes bibliográficos
Main Authors: Zhu, Kuichun, Gerbino, Elvira, Beaupre, Darrin M., Mackley, Paul A., Muro-Cacho, Carlos, Beam, Craig, Hamilton, Andrew D., Lichtenheld, Mathias G., Kerr, William G., Dalton, William, Alsina, Melissa, Sebti, Saïd M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895008/
https://ncbi.nlm.nih.gov/pubmed/15728126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4307
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