Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra®, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours

This phase I trial was designed to determine the safety and maximum tolerated dose (MTD) of tipifarnib in combination with gemcitabine and cisplatin in patients with advanced solid tumours. Furthermore, the pharmacokinetics of each of these agents was evaluated. Patients were treated with tipifarnib...

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Bibliografiske detaljer
Main Authors: Siegel-Lakhai, W S, Crul, M, Zhang, S, Sparidans, R W, Pluim, D, Howes, A, Solanki, B, Beijnen, J H, Schellens, J H M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2005
Fag:
Clinical Study
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361514/
https://ncbi.nlm.nih.gov/pubmed/16251868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602850
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